Endocrine Abstracts

Transient activation of Src oncoprotein can mediate an epigenetic switch from immortalized breast cells to a stably transformed line that forms self-renewing mammospheres that contain cancer stem cells (CSCs). Src activation triggers an inflammatory response mediated by NF-kB that directly activates Lin28 transcription and rapidly reduces the level of let-7 microRNAs. Let-7 inhibits IL6 expression, and IL6 activates STAT3. Importantly, IL6 activates NF-kB, thereby completing a...